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Written By Rohan Wiese
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Updated on April 21st, 2026
Have you ever run into Outlook Error 0x80070021 when try to open your emails, and couldn’t figure out why it happens? This error in Microsoft Outlook usually shows up when another program is using the same file, which stops you Outlook to finish the task. Moreover, it may disrupt your workflow and make email management more difficult, particularly when you need immediate access. In this article, we will cover the year 2026 most reliable approaches that fix the Outlook error and a professional Outlook PST Recovery Software.
TL;DR: The error appears when Outlook can’t access a file due to conflicts or restrictions. You can fix it by closing background apps, disabling add-ins or antivirus software, checking permissions, or using a PST repair tool if the file is damaged.
Outlook Error Code 0x80070021 is a Windows-related error that occurs when Outlook tries to access a file that is used by another process. It appears with a message that indicates that the file cannot be accessed because it is locked. These issues occur when users export Outlook data to a PST file or access large PST files.
It is important to understand the root cause of error Code 0x80070021, which can help you to fix the problem in a more effective way.
Below are some of the effective solutions you can try to resolve this issue:
Sometimes, this error occurs because another application is using the same file.
This makes sure that no file is locked by another process.
Antivirus programs may interfere with Outlook operations.
When you run Outlook in Safe Mode, you can prevent Outlook 0x80070021. Therefore, it helps to identify the add-in issues.
This makes sure that you have proper access to the file location on your computer.
If your Outlook PST file is corrupted and displaying errors like 0x80070021, you can use the Outlook PST Recovery Tool to fix the issue. This software is made to repair damaged PST files and resolve alignment-related problems without affecting your data. Also, it helps with Outlook Error 0x80040600, which allows users to recover their emails. In addition, this tool works on both Windows and Mac systems, which makes it a flexible option for users.
Note: If you encounter the Outlook error 0x80040116 or 0x8004010f, then read our detailed guide.





To prevent this error in the future, follow these best practices:
When Outlook does not perform well, it makes difficulty to back up data. Follow this guide and identify the root cause, and then apply the method to resolve the problem. With the best practice, you can prevent the Outlook error 0x80070021 and make sure a smooth performance.
Ans. It indicates that Outlook cannot access a file because it is being used by another process or application.
Ans. This usually happens when the PST file is locked, too large, or being accessed by another application.
Ans. Common triggers include antivirus interference, add-in conflicts, file corruption, or insufficient permissions.
Ans. Yes, it is a relatively common error, especially during PST export or backup operations.
Ans. Yes, faulty or incompatible add-ins can interrupt Outlook processes and lead to this error.
About The Author:
Rohan Wiese is a content and website optimization expert who helps blogs and businesses grow organically. He specializes in enhancing content quality, improving site structure, and increasing online visibility through smart, practical, and easy-to-implement strategies that drive long-term results.
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